Medicinal cannabis in Germany - Business Report

171 Confidential __________________________________________________________________________________ Product/ active substance DDD Costs in Euro Remarks Cannabis flowers 0.2 up to 3 g/day 18 - 22 € A daily defined dose cannot be determined precisely for flowers. This may be the case at some point for the individual varieties. Cannabis extracts ? Very difficult to assess, due to the diversity of products, suppliers and processes Cannabis oils ? Very difficult to assess, due to the diversity of products, suppliers and processes Dronabinol Alcoholic solution 10 mg/ml (30 drops) /day Capsule 2,5/5/10 mg 1 to 6 capsules/day Oily drops 25 mg/ml 12 drops/day So far, no recommended DDD according to WiDO and WHO Canemes® 3 mg/day 51,29 € Sativex® 8 sprays 2,7 mg/THC + 2,5 mg CBD 8,24 € Epidiolex® ? CannEpil® ? Table 17: Cannabis products and DDD costs Unfortunately, due to the unavailability of these indicators for several commonly used Cannabis preparations, we have not been able to pursue this approach. 11.4 Trend projections of Cannabis prescriptions 2018-2023 An at least comprehensible link between past (undoubtedly short) developments on the Cannabis market and possible "futures" can be established by trend analyses and trend projections. The first useful indicators are the number of Cannabis prescriptions issued by doctors at the expense of SHI patients and the turnover reimbursed to pharmacies by the SHI funds. As long as no better data are available, they are to be supplemented, as before, by proportional estimates for prescriptions and sales in the private physician and hospital sectors. Between the beginning of 2018 and mid-2019, the development of SHI Cannabis prescriptions was characterised by largely steady growth, strong growth in preparations and at least positive growth in finished drugs. If the current linear trend is extended (separately for the two sub-markets) over a fur- ther five years, the 140 thousand Cannabis prescriptions in 2018 will increase almost threefold to 541 thousand prescriptions by 2023. The linear trend only takes into account the average quarterly increase in the number of Cannabis prescriptions to date, but not their internal growth dynamics. If this is also taken into account by ex- ponential trend extrapolations in both sub-markets, the result for all Cannabis prescriptions together is an increase that grows with each year. The 140,000 recipes in 2018 will then become almost 4 million recipes by 2023.